Summary
Epigenetic programming of the immune system is marked by specific DNA methylation events that can be used to identify and quantify immune cells in biological samples. The application of bioinformatic tools to accomplish cell profiling using DNA methylation is termed “immunomethylomics”. Cancer development evolves through an interaction of the immune system with the transformed cell as it undergoes clonal selection. Systemic inflammation and associated immunosuppression are common in many types of malignancy including those of the central nervous system. Our research explores the role of immune cells in cancer risk and outcomes. A specific goal of the research is to improve brain tumor patient survival by applying immunomethylomic approaches within a well characterized epidemiological framework. ResearchGate Description
Who we are
We are a group of researchers from around the country who are interested in Immunomethylomics.
1. Christensen Lab
Christensen Lab @ Dartmouth College
2. Kelsey Lab
Kelsey Lab @ Brown University
3. Houseman Lab
Houseman Lab @ Oregon State University
4. Koestler Lab
Koestler Lab @ University of Kansas Medical Center
5. Wiencke Lab
Wiencke Lab @ University of California, San Francisco
Research
Immunomethylomics
Software
We release freely distributed open-source software related to our work.
1. RefFreeEWAS
Reference free cell mixture deconvolution.
2. methyLiftover
Cross-platform DNA methylation data integration
Contact
Email the group at immunomethylomics [at] gmail.com